Studies indicate that it works as well as or slightly better than fosamax and other bisphosphonates, such as actonel and boniva.

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Allergic reactions Skin rashes including Stevens-Johnson syndromeblisters and peeling skinHypercalcemiatoo much calcium in the bloodPeripheral edemaswellingGastric or duodenal ulcers Femur fractures Dead Jaw Syndromealso known as osteonecrosisa condition characterized by swellinginfection and bone death in the jawEsophageal erosion with bleeding Esophageal perforation Hypocalcemialow blood calcium)

Some side effects of alendronate may occur that usually do not need medical attentionThese side effects may go away during treatment as your body adjusts to the medicineAlsoyour health care professional may be able to tell you about ways to prevent or reduce some of these side effectsCheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Aspirin and NSAIDs drugsibuprofennaproxen and anaproxcause increased stomach irritation Iron supplements and magnesium products prevent Fosamax absorption Antacids makes Fosamax less effective.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapyradiationor steroidsOther risk factors include blood clotting disordersanemialow red blood cellsand a pre existing dental problem.

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precautions for elective surgery are now recommended for those who have taken fosamax for more than three years although the risk of osteonecrosis is very small.